After a series of mysterious deaths, high schooler Yuji Itadori finds himself involved with the supernatural world when he consumes a cursed object to save his friends. This act binds him to a powerful Curse, Ryomen Sukuna, and he is then enrolled in Jujutsu High, a secret organization of Jujutsu Sorcerers, to train and combat Curses. Yuji, alongside his classmates Megumi Fushiguro and Nobara Kugisaki, battles malevolent spirits while striving to control Sukuna's power within him.